The fundamental and translational research conducted within Berkeley Lab’s Energy Sciences Area emphasizes discovery, design, and understanding of materials and chemical, biochemical, and physical processes at the level of electrons, atoms, and molecules. Through this research, we seek solutions to the biggest global challenges impacting our planet in clean energy, microelectronics, quantum information, and beyond through a deeper understanding of the interactions between energy and matter. This research is carried out via collaborative teams across multiple scientific disciplines developing and using advanced instrumentation, theory and computation, synthetic protocols, and nanofabrication techniques, and involving crosscutting research centers with numerous external partners and national user facilities that serve thousands of users per year from around the world.